Itokawa regolith samples recovered by Hayabusa JAXA mission provide an opportunity to study the physical properties of asteroidal regolith, and quantifying the effects of space weathering in asteroidal materials. Future exploration, and particularly landing, of undifferentiated bodies will require increasing our knowledge about the mechanical properties of regolith-bearing surfaces. In the framework of our expertise on chondrites we plan a careful characterization of Itokawa’s micrograins components. Once the mineralogical characterization will be made, we propose the use of nanoindentation to infer the mechanical properties of Itokawa’s mineral phases, and the overall behavior of the regolith grains in front of loading forces. This technique has been recently applied by our team for the first time in chondrites, with very significant results for deflecting Potentially Hazardous Asteroids, PHAs (Moyano-Cambero et al., 2016a,b,c)